Inhibiting myostatin reverses muscle fibrosis through apoptosis
نویسندگان
چکیده
160 words Text: 3,690 words Condensed Title: Myostatin Inhibition Reverses Fibrosis © 2012. Published by The Company of Biologists Ltd. Jo ur na l o f C el l S ci en ce A cc ep te d m an us cr ip t JCS online publication date 8 June 2012 Myostatin Inhibition Reverses Fibrosis
منابع مشابه
Inhibition of myostatin reverses muscle fibrosis through apoptosis.
Skeletal muscle fibrosis is a defining feature of the muscular dystrophies in which contractile myofibers are replaced by fibroblasts, adipocytes and extracellular matrix. This maladaptive response of muscle to repetitive injury is progressive, self-perpetuating and thus far, has been considered irreversible. We have previously shown that myostatin, a known endogenous modulator of muscle growth...
متن کاملMyostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells.
Myostatin mutations in mice and cattle are associated with increased muscularity, suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the hypothesis that myostatin inhibits muscle cell growth, we examined the effects of recombinant myostatin in mouse skeletal muscle C2C12 cells. After verification of the expression of cDNA constructs in a cell-free system and in t...
متن کاملRelationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis.
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملRelationships between Tgf-β1, Myostatin, and Decorin: Implications for Skeletal Muscle Fibrosis*
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
متن کاملMolecular and Cellular Pathobiology Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is understood about how the severe loss of skeletal muscle characterizing this condition occurs. In the current study, we tested the hypothesis that the muscle protein myostatin is involved in mediating the pathogenesis of cachexia-induced muscl...
متن کامل